2006 Mercedes-Benz E350 Service and Repair Manual

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Factory-Grade Data

2006 Mercedes-Benz E350 service and repair manual — a detailed, factory-style reference for maintenance, diagnostics, and repair. Use it to confirm correct procedures, specifications, and system coverage before you start work.

Designed for technicians and DIY owners, this manual helps you troubleshoot accurately, follow step-by-step repair procedures, and reference wiring diagrams and system sections quickly while you work.

What’s included

  • Step-by-step repair procedures and service information
  • Specifications and reference data (where provided)
  • Wiring diagrams and electrical sections
  • Powertrain, brakes, steering, suspension, HVAC and more

Trims covered

  • 4Matic Wagon 4-Door
  • Elegance Sedan 4-Door
  • Base Sedan 4-Door
  • 4Matic Sedan 4-Door
  • Sport Sedan 4-Door
  • Base Wagon 4-Door

Engines covered

  • 3.5L 3498CC V6 GAS DOHC Naturally Aspirated

Index / Table of contents

  • Body
  • Brakes
  • Chassis Electrical
  • Driveline
  • Engine Cooling
  • Engine Electrical
  • Engine Mechanical
  • Engine Performance & Emission Controls
  • Fuel System
  • General Information & Identification
  • Heating, Ventilation, & Air Conditioning
  • Hybrid & Electric Vehicle Systems
  • Steering
  • Suspension
  • Transmission, Clutch, & Transfer Case
  • Wiring Diagrams

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Vehicle Safety Data

2006 Mercedes-Benz E350 Recalls & Complaints

NHTSA #22V95400023/12/2022Component: VISIBILITY:SUN/MOON ROOF ASSEMBLY

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2001-2011 C-Class, CLK, E-Class, and CLS vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The glass sunroof pan

Consequence

A detached sunroof panel may become a road hazard, increasing the risk of a crash.

Remedy

Dealers will inspect and replace the sunroof panel as necessary free of charge. Owner notification

NHTSA #19V91800020/12/2019Component: VISIBILITY:SUN/MOON ROOF ASSEMBLY

Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2001-2011 vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly resulting in the glass panel detachin

Consequence

A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk o

Remedy

MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding r

NHTSA #21V19600019/03/2021Component: VISIBILITY:SUN/MOON ROOF ASSEMBLY

Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2006-2007 C350, C230, C280, CLK350, E320CDI, E350 Wagon, E350, 2006 C55 AMG, CLK500, CLS500, CLS55 AMG, E500 Wagon, E500, E55 AMG, 2007 CLK550, C

Consequence

A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk o

Remedy

MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding r

TSB #11032518

The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline for all dealer returns is no later than Thursday, May 14, 2026. After May 14th, returns of th

TSB #11031882

The part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing PDC. The deadline for all dealer returns is no later than Thursday, May 7, 2026. After May 7th, returns of thes

TSB #11031732

In our continuing efforts to enhance the satisfaction of our customers, Mercedes-Benz USA, LLC (MBUSA) has decided to extend the warranty for certain fuel tank components in certain Mercedes-Benz vehicles. Specifically, the warranty on the

TSB #11031725

The purpose of this letter is to advise you of additional benefits that Mercedes-Benz is providing to you regarding your vehicle ownership. Whats Included In our continuing efforts to assure the proper performance of Mercedes-Benz products

TSB #11031629

To enhance the satisfaction of our customers, avoid further costs of litigation and return focus to its core businesses, Mercedes-Benz USA, LLC (MBUSA) entered into a settlement regarding claims relating to the replacement of sintered steel

TSB #11031595

In our continuing efforts to enhance the satisfaction of our customers, Mercedes-Benz USA, LLC (MBUSA) has decided to extend the warranty for certain fuel tank components in certain Mercedes-Benz vehicles. Which Vehicles: gasoline-fueled, n

TSB #11031585

The warranty on the SBC Hydraulic Unit for MY 2003-2006 Model 211, MY 2006 Model 219, and Model Year 2003-2012 Model 230 was extended from the original 4 years/50,000 miles to 25 years with no mileage limitation. The SBC Hydraulic Unit exte

TSB #11031580

Complaint Headlamp, front fog lamp leaky or fogged. Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the headlamp. If a pressure compe

Showing the 8 most recent of 111 technical service bulletins on file with NHTSA.

20151005Component: AIR BAGSCrash reported7 injured1 fatalities

I AM REPORTING A VERY SERIOUS, DISTURBING, SHOCKING AND TRAGIC ACCIDENT ON 9/12/2015 ON RANDALL ROAD IN ELGIN, IL USA AT 2:35 PM JUST AFTER BIG TIMBER ROAD SIGNAL.MY SOUTHBOUND 2006 MERCEDES BENZ E350

20151005Component: STRUCTURE:BODYCrash reported7 injured1 fatalities

I AM REPORTING A VERY SERIOUS, DISTURBING, SHOCKING AND TRAGIC ACCIDENT ON 9/12/2015 ON RANDALL ROAD IN ELGIN, IL USA AT 2:35 PM JUST AFTER BIG TIMBER ROAD SIGNAL.MY SOUTHBOUND 2006 MERCEDES BENZ E350

20151005Component: ENGINECrash reported7 injured1 fatalities

I AM REPORTING A VERY SERIOUS, DISTURBING, SHOCKING AND TRAGIC ACCIDENT ON 9/12/2015 ON RANDALL ROAD IN ELGIN, IL USA AT 2:35 PM JUST AFTER BIG TIMBER ROAD SIGNAL.MY SOUTHBOUND 2006 MERCEDES BENZ E350

20171007Component: ENGINECrash reported2 injured

MY 2006 MERCEDES BENZ 350 E SERIES HAD GOTTEN IN A ACCIDENT DUE TO THE CAR STALLING OUT. I HAVE A CODE READER AND WILL PROVIDE THE NECESSARY PICTURES I TOOK THE DAY PRIOR OF THE ACCIDENT.

20170404Component: SERVICE BRAKESCrash reported1 injured

TL* THE CONTACT OWNS A 2006 MERCEDES-BENZ E350. WHILE DRIVING APPROXIMATELY 25 MPH, THE CONTACT CAME TO AN ABRUPT STOP AND THE BRAKE PEDAL FAILED TO RESPOND WHEN DEPRESSED. AS A RESULT, THE CONTACT CR

Showing the 5 most serious of 482 complaints filed with NHTSA.

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